Alopecia areata solution 2013

Postato . La categoria: Annunci

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Open label treatment with IL kenalog at the dose deemed most appropriate may be administered after the 1st 6 months in nonresponders or partial responders.It is administered via injection into the scalp and appears to have some efficacy for patients with mild to moderate alopecia areata.Intralesional Saline (Placebo): Patients will receive intradermal injection of study medication once per month to all, or as many as possible, areas of hair loss for a total of 6 months.Injections will be performed at baseline, weeks 4, 8, 12, 16 and 20.AA represents the second most common form of hair loss, and causes significant disfigurement and psychological distress to affected individuals.In addition, there is disagreement between clinicians regarding the dose of intralesional triamcinolone (IL TAC) that is considered most effective.Triamcinolone (Kenalog) is a steroid solution that has been used as treatment for alopecia areata for over 50 years.The investigators currently do not have objective data on the frequency of occurrence of successful regrowth, the duration of response or the incidence of side effects.Intralesional Triamcinolone at a strength of 10 mg/ml.

Alopecia areata is apparently triggered when the individual's own immune system attacks hair follicles on the scalp or body resulting in hair loss ranging from single patches on the scalp (patch type alopecia areata) to loss of every hair on the scalp and body (alopecia universalis).Patients will receive intradermal injection of study medication once per month to all, or as many as possible, areas of hair loss up to the maximum dose of 30 mg IL TAC per month, for a total of 6 months.Intralesional Triamcinolone 10mg/ml (IL TAC 10 mg/ml): Patients will receive intradermal injection of study medication once per month to all, or as many as possible, areas of hair loss up to the maximum dose of 30 mg IL TAC per month, for a total of 6 months.The investigators will also perform skin biopsies of the scalp and draw blood at selected time points in order to examine the immunohistochemical/pathological response in scalp hair follicles and the systemic circulation to treatment with IL TAC for alopecia areata.After the 1st 6 months non or partial responders may be treated for 6 months with open label triamcinolone at the dose deemed appropriate by the investigator.

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