Alopecia areata linear opinioni

Postato . La categoria: Rughe

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A variety of effects on irradiated keratinocytes have been documented. Adhesion molecules are also induced in post capillary venules, facilitating the entry of lymphocytes into the skin.Various complement deficiencies, such as C2 and C4, as well as deficiencies of other components related to the classical pathway have been associated with SLE and SCLE.Binding of antibody such as anti-SSA, anti-SSB, or anti-RNP to the cell membrane starts a whole immunologic cascade that culminates in the production of cutaneous lupus lesions.Some of the common types include chronic cutaneous lupus erythematosus (LE), which includes localized and generalized discoid lupus erythematosus (DLE), hypertrophic LE (a form of DLE), tumid LE, and lupus panniculitis.In DLE compliment deficiencies are less common, but occasional deficiencies of C1 inhibitor, C1Q, C2 and C4 have been reported.The treatment options are fairly similar for all the different types of cutaneous LE, although frequently patients with systemic LE require additional therapy for systemic manifestations of the disease.Cutaneous lupus erythematosus encompasses at least 10 to 15 different clinical presentations.It is easy to imagine how compromise of immune complex clearance could influence lupus development and severity.Cutaneous lupus erythematosus has a variety of clinical presentations, but treatment is similar for the different forms.Optimal use of the antimalarials as well as alternative therapy options are discussed.

Subacute cutaneous LE and systemic LE each have several different cutaneous presentations.The antimalarials remain the cornerstone of treatment because of their effectiveness and safety.In particular, a polymorphism of tumor necrosis factor-alpha (TNF-alpha) may be important in certain photosensitive patients with SCLE.These relationships are not surprising in that complement is important in opsonization of immune complexes which allows clearance.Complement plays a role in many different aspects of lupus.

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